2019
October 2019: Carolyn and Napatra's paper on factors predictive of complete remission after rituximab therapy for pemphigus is published in JAMA Dermatology. Thanks to JAMA Dermatology for their podcast featuring our article
October 2019: Congratulations to Sangwook for his plenary presentation on MuSK CAAR T cells for myasthenia gravis at the American Neurological Association meeting in St. Louis, which was highlighted as a featured abstract
September 2019: DSG3-CAART IND receives FDA clearance to initiate the first-in-human DesCAARTes trial in mucosal pemphigus vulgaris! The Payne lab is proud and grateful to have worked with the experienced Penn/CHOP teams that supported the IND, in alliance with Cabaletta Bio. Many thanks to the Penn/CHOP teams including preclinical (Milone/Fraietta labs, vet school Comparative Pathology Core, Stem Cell and Xenograft Core), manufacturing (Cell and Vaccine Production Facility, CHOP vector core), and clinical/regulatory (Center for Cellular Immunotherapies, Translational Correlative Studies Laboratory, the DesCAARTes investigators David Porter/Rob Micheletti/Victoria Werth/Noelle Frey/Elizabeth Hexner, Daniel Shin). We are also thankful for the support from offices throughout Penn who helped us to usher this technology from the bench to the clinic (Penn Center for Innovation, Office of General Counsel, Office of Clinical Research, Penn Center for Precision Medicine, Institute for Immunology).
September 2019: Christoph and Daniel's review on genetically engineered therapies for autoimmunity is published in Current Opinions in Immunology
May 2019: Welcome to Ellyssa Sherman, a master's student at Thomas Jefferson University, who will be completing her thesis on B cell tolerance checkpoints in pemphigus vulgaris
May 2019: Establishment of the Penn Clinical Autoimmunity Center of Excellence, funded by NIAID. Aimee is proud to be working with Amit Bar-Or, MD, and Nina Luning Prak, MD, PhD, to investigate B cells as drivers of autoimmunity in a broad range of autoimmune diseases. Thanks to Knowledge@Wharton SiriusXM Channel 132 and the Daily Pennsylvanian for featuring our new center. |
March 2019: Christoph delivers the Quo Vadis Lecture at the ADF meeting in Munich
2018
October 2018: Eric writes an awesome blogpost for Science Trends on his recent paper published in Cell Reports. Aimee is lamenting her poor social media skills so please share, tweet, and retweet!
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October 2018: Aimee is very excited to be working with Nicky Mason on a new Transformative R01 research award to develop novel cellular therapies for canine cancers and autoimmune diseases.
Also, welcome to Baomei Wang, a new senior research investigator who will be spearheading the canine CAART project along with Xuming Mao and Daniel Lundgren |
August 2018: Christoph and Eric's paper on isotype-specific repertoire cloning in pemphigus is published in Cell Reports
August 2018: Welcome back Daniel Lundgren! Daniel worked in the lab as an undergraduate and we are super excited to have him back as a research specialist focusing on preclinical development of CAART technology
June 2018: Carolyn's oral presentation at the International Investigative Dermatology meeting on factors predictive of complete remission off therapy after rituximab is picked up by Dermatology News
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May 2018: Aimee helps to organize the International Pemphigus and Pemphigoid Foundation 5th Scientific Meeting, Pemphigus and Pemphigoid: A New Era of Translational and Clinical Science, May 15-16 in Orlando, FL. The meeting report is published in Frontiers in Medicine.
May 2018: Congratulations on medical school graduation, Dr. Nina Ran and Dr. Dr. Eric Mukherjee! May 2018: Welcome to UVA undergraduate Sophie Breedveld who is joining us for the summer |
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May 2018: Jinmin's review on applications of CAR technology to immune-mediated diseases is published in Cell and Gene Therapy Insights
May 2018: Congratulations to Nina on the successful defense of her Masters in Translational Research, which investigated tolerance checkpoints in pemphigus vulgaris through single B cell receptor profiling
February 2018: Payne lab welcomes Baby Oh (Oh Baby!)
May 2018: Congratulations to Nina on the successful defense of her Masters in Translational Research, which investigated tolerance checkpoints in pemphigus vulgaris through single B cell receptor profiling
February 2018: Payne lab welcomes Baby Oh (Oh Baby!)
2017
September 2017: Welcome to postdoctoral fellow Sangwook Oh, PhD, previously from Seoul National University
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June 2017: Mike Milone and Aimee receive a Penn Center for Precision Medicine Accelerator Fund Award to support the preclinical development of DSG-CAART technology
May 2017: Xuming's paper on Stat3 regulation of desmoglein 3 transcription is published in JCI Insight April 2017: Christoph and Aimee travel to Washington, DC to accept the "Top 10" Clinical Research Achievement Award (highlighted at 11:30). |
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